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Baliga MS, Wang H, Zhuo P, Schwartz JL, Diamond AM

Intact glutathione is too big to pass through the intestinal wall efficiently

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The resulting oxidized form of GSH either reacts with another GSH molecule to form GSSG or with cysteine groups on cellular proteins to form protein GSH mixed disulfides, a process known as protein glutathionylation. This latter reaction can change the proteins structure and function, which can, in turn, evoke a functional change within the cell

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(2023) The kinetics of glutathione in the gastrointestinal tract of weaned piglets supplemented with different doses of dietary reduced glutathione